Water → 3-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1-one

HRID 2351578Notes

Reaction equation

HRID 2351578 reaction equation
C([C:4]1([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:13])[CH2:5]1)(O)=O.O.C(OC(=O)C)C>CN1CCCC1=O>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH:4]2[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6](=[O:13])[CH2:5]2)=[CH:19][CH:18]=1

Participants

5

Reactant 3

HCID 962WaterHCID 8857Ethyl AcetateHCID 14737099HCID 14737099, compound

Product 1

HCID 30177883-(4-Fluorophenyl)-2,3-dihydro-1H-inden-1-one

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The following operations are performed under dry nitrogen. A solution of 40.0 gr 3-carboxy-3-(4-fluorophenyl)-indan-1-one in 50 ml N-methylpyrrolidone is heated to 100° C. and stirred for 2 hours at this temperature. The reaction-mixture is cooled and poured into 250 ml water. Subsequent extractive work-up with ethylacetate give the product 3-(4-fluorophenyl)-indan-1-one.

Workup

  1. temperatureThe reaction-mixture is cooled

Sources & evidence

ORD record
ord-c155566c42254584b25ac25f70292ef7
Source dataset
uspto-grants-1989_10
Patent number
US04873344

Reaction notes

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