Chloroform → 1-Chloro-2-methylpropyl propanoate
Reaction equation
[C:1]([Cl:5])(=[O:4])[CH2:2][CH3:3].[CH:6](=[O:10])[CH:7](C)[CH3:8].[CH:11](Cl)(Cl)Cl>[Cl-].[Zn+2].[Cl-]>[C:6]([O:4][CH:1]([Cl:5])[CH:2]([CH3:11])[CH3:3])(=[O:10])[CH2:7][CH3:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
To a vigorously stirred, ice-cooled solution of propionyl chloride (1407 g, 14.8 moles) in 3A sieve-dried chloroform (3000 ml) was added zinc chloride (7.4 g) followed by the dropwise addition (exotherm) of isobutyraldehyde (1132 g, 14.8 moles) at such a rate that the temperature was maintained at 25° C. (three hours).
Sources & evidence
- ORD record
- ord-05aba4964ae942478be0a2251e9b598d
- Source dataset
- uspto-grants-1989_10
- Patent number
- US04873356
Reaction notes
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