反应详情

温度

80 °C

To a solution of 3-(1-dodecynyl)benzaldehyde (23.0 g) in toluene (150 ml) was added carbethoxymethylenetriphenylphosphorane (35.5 g) in one portion. The mixture was warmed at 80° C. for 5 hr, allowed to cool to room temperature, and concentrated in vacuo. The residue was flash chromatographed over silica gel (eluted with ethyl acetate/hexane/1:15). The appropriate fractions were collected and evaporated to afford 21.1 g (73%) of product.

1. temperatureto cool to room temperature
2. concentrationconcentrated in vacuo
3. customchromatographed over silica gel (eluted with ethyl acetate/hexane/1:15)
4. customThe appropriate fractions were collected
5. customevaporated