1,4-Dioxane hydrochloride → HCID 178478701, compound

HRID 2351824Notes

Reaction equation

HRID 2351824 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:42])[CH:9]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:30]=2)[NH:10][C:11]([C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][NH:20]C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)=[O:12])=[CH:3][CH:2]=1.[ClH:43].O1CCOCC1>O1CCOCC1>[ClH:43].[ClH:43].[N:1]1[CH:6]=[CH:5][C:4]([NH:7][C:8](=[O:42])[CH:9]([CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([O:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH:30]=2)[NH:10][C:11]([C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][NH2:20])[CH2:15][CH2:14]2)=[O:12])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178453616HCID 178453616, compound

Product 1

HCID 178478701HCID 178478701, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The compound (III) (1.60 g) was dissolved in dry 1,4-dioxane (5 ml) and a 4N-hydrogen chloride/1,4-dioxane solution (30 ml) was added, followed by stirring at room temperature. After one hour, the precipitated crystalline substance was recovered by filtration, followed by washing with diethylether, and after drying in vacuo, the desired N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalanine 4-pyridylamide dihydrochloride (1.57 g), which was confirmed by NMR spectrum analysis, was obtained in the form of a hygroscopic white powder.

Workup

  1. filtrationthe precipitated crystalline substance was recovered by filtration
  2. washby washing with diethylether
  3. customafter drying in vacuo
  4. customwas obtained in the form of a hygroscopic white powder

Sources & evidence

ORD record
ord-61e2b5faaa7846fbaec60406f89c0ddc
Source dataset
uspto-grants-1989_10
Patent number
US04873253

Reaction notes

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