1,4-Dioxane hydrochloride → HCID 178478701, compound

Participants

Reaction Steps

The compound (III) (1.60 g) was dissolved in dry 1,4-dioxane (5 ml) and a 4N-hydrogen chloride/1,4-dioxane solution (30 ml) was added, followed by stirring at room temperature. After one hour, the precipitated crystalline substance was recovered by filtration, followed by washing with diethylether, and after drying in vacuo, the desired N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalanine 4-pyridylamide dihydrochloride (1.57 g), which was confirmed by NMR spectrum analysis, was obtained in the form of a hygroscopic white powder.

Provenance & Evidence