Diethyl Ether → HCID 178479226, compound

HRID 2351827Notes

Reaction equation

HRID 2351827 reaction equation
C(OC([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([NH:18][C:19](=[O:36])[CH:20]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:24]=2)[NH2:21])=[O:17])[CH2:12][CH2:11]1)=O)(C)(C)C.C(OCC)C.[ClH:42].O1CCOCC1>>[ClH:42].[NH2:8][CH2:9][C@H:10]1[CH2:11][CH2:12][C@H:13]([C:16]([NH:18][C:19](=[O:36])[CH:20]([CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:24]=2)[NH2:21])=[O:17])[CH2:14][CH2:15]1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 204431481,4-Dioxane hydrochlorideHCID 178453622HCID 178453622, compound

Product 1

HCID 178479226HCID 178479226, compound

Procedure

The compound (I) (0.25 g) was dissolved in a 4N-hydrogen chloride/1,4-dioxane solution (0.76 ml) and the solution was stirred at room temperature for 30 minutes. Diethyl ether (10 ml) was added and the precipitated substance was recovered by filtration. After drying, N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalanine amide hydrochloride (0.18 g), which was confirmed by an IR analysis, was obtained in the form of a white powder.

Workup

  1. filtrationthe precipitated substance was recovered by filtration
  2. customAfter drying
  3. customwas obtained in the form of a white powder

Sources & evidence

ORD record
ord-e482cc75b9114273918c3c9a28ddb9fb
Source dataset
uspto-grants-1989_10
Patent number
US04873253

Reaction notes

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