1,4-Dioxane hydrochloride → HCID 178470930, compound

HRID 2351829Notes

Reaction equation

HRID 2351829 reaction equation
C(=O)(O)O.C(OC(C1CC[N:13](C(N)=O)[CH2:12]C1)=O)C.N([C:23]1[CH:49]=[CH:48][C:26]([C:27]([NH:29][CH:30]([C:45]([OH:47])=[O:46])[CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([O:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:33]=2)=[O:28])=[CH:25][CH:24]=1)C(N)=N.[ClH:50].O1CCO[CH2:53][CH2:52]1>CCCCCC>[ClH:50].[CH2:52]([O:47][C:45](=[O:46])[CH:30]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([O:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH:33]=1)[NH:29][C:27]([C@H:26]1[CH2:48][CH2:49][C@H:23]([CH2:12][NH2:13])[CH2:24][CH2:25]1)=[O:28])[CH3:53]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178469238HCID 178469238, compound

Product 1

HCID 178470930HCID 178470930, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To the compound (III) (0.60 g), a 4N-hydrogen chloride/1,4-dioxane solution (5 ml) was added, followed by stirring at room temperature for one hour. Hexane (50 ml) was then added and the upper layer was removed by decantation. This procedure was repeated twice and the residue was solidified with ethyl acetate. Thus, N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalanine ethyl ester hydrochloride (0.44 g) was obtained in the form of a white powder.

Workup

  1. customthe upper layer was removed by decantation

Sources & evidence

ORD record
ord-26d6b109abc449998422931549de6258
Source dataset
uspto-grants-1989_10
Patent number
US04873253

Reaction notes

Loading…