1,4-Dioxane hydrochloride → HCID 178470930, compound

Participants

Reaction Steps

To the compound (III) (0.60 g), a 4N-hydrogen chloride/1,4-dioxane solution (5 ml) was added, followed by stirring at room temperature for one hour. Hexane (50 ml) was then added and the upper layer was removed by decantation. This procedure was repeated twice and the residue was solidified with ethyl acetate. Thus, N-(trans-4-aminomethylcyclohexylcarbonyl)-3-phenoxy-DL-phenylalanine ethyl ester hydrochloride (0.44 g) was obtained in the form of a white powder.

Provenance & Evidence