Hydrochloric Acid → HCID 14573468, compound

HRID 2351840Notes

Reaction equation

HRID 2351840 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[CH:12][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:10][N:9]=2)=[CH:4][CH:3]=1.Cl[C:27]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])=[O:28].N1C=CC=CC=1.Cl>C(Cl)(Cl)(Cl)Cl>[CH2:30]([O:29][C:27]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[CH:10][C:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:12][N:13]=2)=[CH:6][CH:7]=1)=[O:28])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 544663Nonyl ChloroformateHCID 1360357064-(5-Dodecyl-2-pyrimidinyl)phenol

Product 1

HCID 14573468HCID 14573468, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

2-(4-Hydroxyphenyl)-5-dodecylpyrimidine (G) (1.0 g) was dissolved in 50 ml of carbon tetrachloride, 0.8 ml of nonyl chlorocarboxylate and 5 ml of pyridine were added, and the mixture was stirred for a while and allowed to stand overnight. 1N Hydrochloric acid was added, and the carbon tetrachloride layer was taken and concentrated. The residue was purified by repeated recrystallization from methanol to obtain (H).

Workup

  1. concentrationconcentrated
  2. customThe residue was purified
  3. customrecrystallization from methanol

Sources & evidence

ORD record
ord-4a725d598f694a748c15d986ca2d9b3f
Source dataset
uspto-grants-1989_10
Patent number
US04874542

Reaction notes

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