Sodium Hydroxide → HCID 13773368, compound

HRID 2351952Notes

Reaction equation

HRID 2351952 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:21])[CH:7]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=1)[C:8]([C:10]([F:13])([F:12])[F:11])=[CH2:9])C>O>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([CH:7]([C:8]([C:10]([F:11])([F:12])[F:13])=[CH2:9])[C:6]([OH:21])=[O:5])=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13773366HCID 13773366, compound

Product 1

HCID 13773368HCID 13773368, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15% Aqueous sodium hydroxide (3 ml) is added to a stirred solution of ethyl-2-(4-chlorophenyl)-3(trifluoromethyl)-but-3-enoate (0.3 g) and the mixture refluxed for 3 hours, cooled to room temperature, diluted with water (10 ml) and extracted with ether. The aqueous phase is acidified with 2N aqueous hydrochloric acid extracted with ether (×3), dried and the solvent evaporated under reduced pressure. Yield 0.25 g nD 1.4898.

Workup

  1. temperaturethe mixture refluxed for 3 hours
  2. extractionextracted with ether
  3. extractionextracted with ether (×3)
  4. customdried
  5. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-7b0c2968a96b43edb0122d05d0bcb48a
Source dataset
uspto-grants-1989_10
Patent number
US04874781

Reaction notes

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