Potassium Carbonate → HCID 14720276, compound

HRID 2351961Notes

Reaction equation

HRID 2351961 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][CH2:23][S:24](Cl)(=[O:26])=[O:25]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[S:24]([CH2:23][Cl:22])(=[O:26])=[O:25])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 77054(Chloromethyl)sulfonyl chlorideHCID 28045454-chloro-N-(pyridin-3-ylmethyl)aniline

Product 1

HCID 14720276HCID 14720276, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 2.6 g. portion of 3-(4-chlorophenylaminomethyl)pyridine was dissolved in dichloromethane with stirring, and to the solution was added 2.1 g. of potassium carbonate and 2.25 g. of chloromethanesulfonyl chloride. The mixture was stirred at ambient temperature for several days, and was then worked up as described in Example 3 to obtain 0.6 g. of the desired product, m.p. 98°-100°.

Workup

  1. additionto the solution was added 2.1 g
  2. stirringThe mixture was stirred at ambient temperature for several days
  3. customto obtain 0.6 g

Sources & evidence

ORD record
ord-95d69af03f754fd9ba2fb229ed3641d7
Source dataset
uspto-grants-1989_10
Patent number
US04874775

Reaction notes

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