Potassium Carbonate → HCID 14720280, compound

HRID 2351964Notes

Reaction equation

HRID 2351964 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:22][N:23]([CH3:28])[S:24](Cl)(=[O:26])=[O:25]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[S:24]([N:23]([CH3:28])[CH3:22])(=[O:26])=[O:25])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 83372Dimethylsulphamoyl chlorideHCID 28045454-chloro-N-(pyridin-3-ylmethyl)aniline

Product 1

HCID 14720280HCID 14720280, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 2.8 g. portion of 3-(4-chlorophenylaminomethyl)pyridine was dissolved in dichloromethane, and to it was added 2.1 g. of potassium carbonate and 1.6 ml. of dimethylsulfamoyl chloride. The mixture was stirred at ambient temperature for 1 day, and was then stirred under gentle heating for 3 days. The solvent was then evaporated under vacuum, and the oily residue was purified by chromatography on silica gel in chloroform to obtain 3.9 g. of the desired product. Its elemental analysis was as follows.

Workup

  1. additionto it was added 2.1 g
  2. stirringwas then stirred
  3. temperatureunder gentle heating for 3 days
  4. customThe solvent was then evaporated under vacuum
  5. customthe oily residue was purified by chromatography on silica gel in chloroform
  6. customto obtain 3.9 g

Sources & evidence

ORD record
ord-c649b2aa0cff468ea4a3ff93e1391b12
Source dataset
uspto-grants-1989_10
Patent number
US04874775

Reaction notes

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