Potassium Carbonate → HCID 14720284, compound

HRID 2351967Notes

Reaction equation

HRID 2351967 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][S:23](Cl)(=[O:25])=[O:24].C(=O)([O-])[O-].[K+].[K+]>ClCCl>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([N:14]([CH2:15][C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[S:23]([CH3:22])(=[O:25])=[O:24])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31297Methanesulfonyl chlorideHCID 4712132HCID 4712132, compound

Product 1

HCID 14720284HCID 14720284, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A 5.5 g. portion of 3-(4-phenoxyphenylaminomethyl)pyridine was dissolved in dichloromethane, and reacted with 1.7 ml. of methanesulfonyl chloride in the presence of 3 g. of potassium carbonate. The mixture was stirred at ambient temperature for several days. It was diluted with dichloromethane, extracted with water, dried over magnesium sulfate, and evaporated under vacuum. The residue was triturated in diethyl ether and petroleum ether, filtered and dried to obtain 6.4 g. of the desired product, m.p. 139°-140°.

Workup

  1. customreacted with 1.7 ml
  2. extractionextracted with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated under vacuum
  5. customThe residue was triturated in diethyl ether
  6. filtrationpetroleum ether, filtered
  7. customdried
  8. customto obtain 6.4 g

Sources & evidence

ORD record
ord-fb00beac4aff4060acc2c37482a01f6a
Source dataset
uspto-grants-1989_10
Patent number
US04874775

Reaction notes

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