Potassium Carbonate → HCID 14720336, compound

HRID 2351997Notes

Reaction equation

HRID 2351997 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:22][S:23](Cl)(=[O:25])=[O:24]>ClCCl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[S:23]([CH3:22])(=[O:25])=[O:24])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31297Methanesulfonyl chlorideHCID 742755HCID 742755, compound

Product 1

HCID 14720336HCID 14720336, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 3.5 g. portion of 3-(4-methylphenylaminomethyl)pyridine was dissolved in 15 ml. of dichloromethane, and 2.7 g. of potassium carbonate and 2 ml. of methanesulfonyl chloride were added. The mixture was stirred overnight under reflux, and was then extracted with 20 ml. of water and evaporated under vacuum. The residue was triturated with diethyl ether and dried to obtain 4.5 g. of the desired product, m.p. 143°-146°.

Workup

  1. temperatureunder reflux
  2. extractionwas then extracted with 20 ml
  3. customof water and evaporated under vacuum
  4. customThe residue was triturated with diethyl ether
  5. customdried
  6. customto obtain 4.5 g

Sources & evidence

ORD record
ord-b12800213f1d4cdea72db70a13c50cb9
Source dataset
uspto-grants-1989_10
Patent number
US04874775

Reaction notes

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