4-Methoxybenzenesulfonyl chloride → 4-Methoxybenzenesulfonamide

HRID 2352065Notes

Reaction equation

HRID 2352065 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[NH4+:14]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH2:14])(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 14923Ammonium Hydroxide

Product 1

HCID 707894-Methoxybenzenesulfonamide

Procedure

Proceeding in a manner similar to that described in Example 1, part B above, 100.42 g (0.486 m) of 4-methoxybenzenesulfonyl chloride from part A above was interacted with ammonium hydroxide and acidified to obtain 69.25 g of 4-methoxybenzenesulfonamide, a white solid which melted at 111.5°-112.5° C. The nuclear magnetic resonance spectrum was in accord with the assigned structure.

Sources & evidence

ORD record
ord-1ba933cd19364693a6281d8713aae096
Source dataset
uspto-grants-1989_10
Patent number
US04874894

Reaction notes

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