2-Acetylthiophene → HCID 13786025, compound

HRID 2352083Notes

Reaction equation

HRID 2352083 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH3:13])([CH3:12])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C:14]([C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)(=O)[CH3:15]>C(Cl)Cl>[CH3:12][C:6]1([CH3:13])[C:7](=[O:11])[NH:8][C:9]2[CH:10]=[C:2]3[C:3](=[CH:4][C:5]1=2)[CH:15]=[C:14]([C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)[NH:1]3

Participants

4

Reactant 2

HCID 69202-AcetylthiopheneHCID 135892296-Amino-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 13786025HCID 13786025, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Analogously to Example 1, 6.8 g. (38 mmole) 6-amino-3,3-dimethylindolin-2-one are diazotised and reduced. Into the solution are added dropwise 10.9 g. (85 mmole) 2-acetylthiophene and the oil which separates out is taken up in methylene chloride, dried and evaporated. As crude product, there are obtained 11.2 g. 2-acetylthiophene-(3,3-dimethyl-2-oxoindoline-6-hydrazone) which is further reacted without purification.

Workup

  1. additionInto the solution are added dropwise 10.9 g
  2. customdried
  3. customevaporated
  4. customAs crude product, there are obtained 11.2 g

Sources & evidence

ORD record
ord-b35207f098ca4b01826b9cfa9575218d
Source dataset
uspto-grants-1989_10
Patent number
US04874756

Reaction notes

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