HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 13650461, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one | HCID 716472 | — |
| Reactant | (1H-1,2,4-Triazol-1-yl)methanol | HCID 1547783 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13650461 | HCID 13650461 | 78.5% |
Reaction Steps
A mixture of 44.3 g of 4-chlorophenyl 1,2,4-triazol-1-yl-methyl ketone, 19.6 g of 1-hydroxymethyl-1,2,4-triazole, 300 ml of toluene, 6 g of acetic acid and 2 ml of piperidine is heated under a water separator until separation of water is complete. The mixture is allowed to cool, and the crystalline precipitate formed is filtered off under suction and washed with diisopropyl ether. 47 g (76% of theory) of 1-(4-chlorophenyl)-2,3-di-(1,2,4-triazol-1-yl)-propan-1-one of melting point 240° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04875928 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-475b72355d8843489b7e16cd3f088483 |
| Source note | uspto-grants-1989_10 |