反应详情

A mixture of 44.3 g of 4-chlorophenyl 1,2,4-triazol-1-yl-methyl ketone, 19.6 g of 1-hydroxymethyl-1,2,4-triazole, 300 ml of toluene, 6 g of acetic acid and 2 ml of piperidine is heated under a water separator until separation of water is complete. The mixture is allowed to cool, and the crystalline precipitate formed is filtered off under suction and washed with diisopropyl ether. 47 g (76% of theory) of 1-(4-chlorophenyl)-2,3-di-(1,2,4-triazol-1-yl)-propan-1-one of melting point 240° C. are obtained.

1. temperatureto cool
2. customthe crystalline precipitate formed
3. filtrationis filtered off under suction
4. washwashed with diisopropyl ether