2,3,5,6-Tetrafluorophenol → HCID 72739626, compound

HRID 2352146Notes

Reaction equation

HRID 2352146 reaction equation
[CH2:1]([Sn:5]([CH2:30][CH2:31][CH2:32][CH3:33])([CH2:26][CH2:27][CH2:28][CH3:29])[CH:6]=[CH:7][CH2:8][CH2:9][C:10]([O:12][Sn](CCCC)(CCCC)CCCC)=[O:11])[CH2:2][CH2:3][CH3:4].[F:34][C:35]1[C:40]([F:41])=[CH:39][C:38]([F:42])=[C:37]([F:43])[C:36]=1O>C1COCC1>[CH2:30]([Sn:5]([CH2:1][CH2:2][CH2:3][CH3:4])([CH2:26][CH2:27][CH2:28][CH3:29])[CH:6]=[CH:7][CH2:8][CH2:9][C:10]([O:12][C:36]1[C:35]([F:34])=[C:40]([F:41])[CH:39]=[C:38]([F:42])[C:37]=1[F:43])=[O:11])[CH2:31][CH2:32][CH3:33]

Participants

4

Reactant 2

HCID 698582,3,5,6-TetrafluorophenolHCID 73653327HCID 73653327, compound

Product 1

HCID 72739626HCID 72739626, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of tri-n-butylstannyl 5-(tri-n-butylstannyl)-4-pentenoate acid (1.0 equiv.) in anhydrous THF at room temperature is added dicyclohexy (1.2 equiv.) (Aldrich) and 2,3,5,6-tetrafluorophenol (1.2 equiv.) (Aldrich). The resulting solution is stirred overnight. The mixture is filtered, the filtrate is concentrated, and the residue is chromatographed to provide 2,3,5,6-tetrafluorophenyl 5-(tri-n-butylstannyl)-4-pentenoate.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated
  3. customthe residue is chromatographed

Sources & evidence

ORD record
ord-5beeb505f9c945a7af571d1e3db25f5c
Source dataset
uspto-grants-1989_10
Patent number
US04876081

Reaction notes

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