Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 235217Notes

Reaction equation

HRID 235217 reaction equation
C[C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.C(S[NH:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]CCCCCCC(O)=O)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH:61]1([N:67]=[C:68]=NC2CCCCC2)CCCCC1>O1CCCC1>[CH3:61][N:67]([C:51]1[CH:50]=[CH:49][CH:48]=[CH:47][N:46]=1)[CH3:68]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 11268547CID 11268547HCID 19032991HCID 19032991, compound

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 500 mg of radicicol, 2.013 g of 12-tritylthioaminododecanoic acid, 60 ml of dry tetrahydrofuran, 848 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 965 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-af23415338fb46ac88cd9c6c3f7989be
Source dataset
uspto-grants-1997_01
Patent number
US05597846

Reaction notes

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