Triethylamine → HCID 14346973, compound

HRID 2352173Notes

Reaction equation

HRID 2352173 reaction equation
C([NH:3][CH2:4][CH2:5][NH:6][CH2:7][CH3:8])C.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([NH:21][C:22]3[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=3)[N:16]=2)[CH:10]=1.[CH2:31](N(CC)CC)[CH3:32]>COCCOC>[CH2:31]([N:6]([CH2:7][CH3:8])[CH2:5][CH2:4][NH:3][C:26](=[O:27])[C:25]1[CH:29]=[CH:30][C:22]([NH:21][C:17]2[N:16]=[C:15]([C:11]3[CH:10]=[N:9][CH:14]=[CH:13][CH:12]=3)[CH:20]=[CH:19][N:18]=2)=[CH:23][CH:24]=1)[CH3:32]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 67105N,N'-DiethylethylenediamineHCID 14346971HCID 14346971, compound

Product 1

HCID 14346973HCID 14346973, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A 1.55 ml portion of diethylethylenediamine was added to a solution of 0.01 mole of 4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid chloride in 50 ml of 1,2-dimethoxyethane. A 10 ml portion of triethylamine was added and the mixture was stirred for 2 hours. The solid was collected, washed with water and recrystallized from absolute ethanol, giving 1.22 g of the desired product, mp 148°-150° C.

Workup

  1. customThe solid was collected
  2. washwashed with water
  3. customrecrystallized from absolute ethanol

Sources & evidence

ORD record
ord-5255d4fa59d34800a3312ab76e669785
Source dataset
uspto-grants-1989_10
Patent number
US04876252

Reaction notes

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