Hydrochloric Acid → HCID 14347194, compound

HRID 2352180Notes

Reaction equation

HRID 2352180 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([NH:20]C(=O)C)=[CH:16][CH:15]=3)[N:8]=2)=[CH:3][CH:2]=1.[ClH:24]>O>[ClH:24].[N:1]1[CH:2]=[CH:3][C:4]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=3)[N:8]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14347143HCID 14347143, compound

Product 1

HCID 14347194HCID 14347194, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 2.85 g amount of N-[4-[[4-(4-pyridinyl)-2-pyrimidinyl]amino]phenyl]acetamide was added to a mixture of 10 ml of concentrated hydrochloric acid and 10 ml of water. The reaction mixture was heated at reflux for 90 minutes, then evaporated in vacuo to obtain a solid. The solid was recrystallized from 3A ethanol/water and gave 2.31 g of the desired product as a yellow crystalline solid, mp 292°-295° C.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 90 minutes
  3. customevaporated in vacuo
  4. customto obtain a solid
  5. customThe solid was recrystallized from 3A ethanol/water

Sources & evidence

ORD record
ord-4b996f85afd147f0a15fc49e8b4f0cbb
Source dataset
uspto-grants-1989_10
Patent number
US04876252

Reaction notes

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