Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 235219Notes

Reaction equation

HRID 235219 reaction equation
[CH3:1][C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.C(CCCCCCCCCCCCCCCC(O)=S)(=O)C.[CH:47]1([N:53]=[C:54]=[N:55][CH:56]2[CH2:61][CH2:60][CH2:59]CC2)CCCCC1>O1CCCC1>[CH3:1][N:53]([C:54]1[CH:59]=[CH:60][CH:61]=[CH:56][N:55]=1)[CH3:47]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 11268547CID 11268547HCID 178467769HCID 178467769, compound

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 120 mg of radicicol, 206 mg of 16-acetylthiohexadecanoic acid, 5 ml of dry tetrahydrofuran, 330 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 235 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-71ebdd569f19466187f0f200acee15e6
Source dataset
uspto-grants-1997_01
Patent number
US05597846

Reaction notes

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