Pyridine → 2-Dimethylaminopyridine

HRID 235220Notes

Reaction equation

C[C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.[C:26]([CH2:28][CH2:29][CH2:30][CH2:31]CCCCCCC(Cl)=O)#[N:27].C(Cl)Cl.[N:44]1[CH:49]=CC=C[CH:45]=1>>[CH3:45][N:44]([C:31]1[CH:30]=[CH:29][CH:28]=[CH:26][N:27]=1)[CH3:49]

Participants

Reactant 4

HCID 1049Pyridine

HCID 6344Dichloromethane

HCID 11268547CID 11268547

HCID 15584310HCID 15584310, compound

Product 1

HCID 218852-Dimethylaminopyridine

Procedure

Following a procedure similar to that described in Example 1, but using 365 mg of radicicol, 11-cyanoundecanoyl chloride (prepared from 1.055 g of 11-cyanoundecanoic acid), 7 ml of dry methylene chloride, 1.21 ml of pyridine and a catalytic amount of dimethylaminopyridine, 707 mg of the title compound were obtained.

Sources & evidence

ORD record: ord-64bbf752fb15412e962e86a10c2ef4c1
Source dataset: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05597846

Reaction notes

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