Dicyclohexylcarbodiimide → 2-Dimethylaminopyridine

HRID 235224Notes

Reaction equation

HRID 235224 reaction equation
[CH3:1][C@H]1OC(=O)C2C(O)=CC(O)=C(Cl)C=2CC(=O)C=CC=C[C@H]2O[C@H]2C1.OCCCCCCCCCC(O)=O.[CH:39]1([N:45]=[C:46]=[N:47][CH:48]2[CH2:53][CH2:52][CH2:51]CC2)CCCCC1>O1CCCC1>[CH3:1][N:45]([C:46]1[CH:51]=[CH:52][CH:53]=[CH:48][N:47]=1)[CH3:39]

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 7430010-Hydroxydecanoic AcidHCID 11268547CID 11268547

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 12, but using 365 mg of radicicol, 471 mg of 10-hydroxydecanoic acid, 25 ml of dry tetrahydrofuran, 516 mg of dicyclohexylcarbodiimide and a catalytic amount of dimethylaminopyridine, 332 mg of the title compound were obtained.

Sources & evidence

ORD record
ord-effcb68e51cd4917a4b016cbe562f2b1
Source dataset
uspto-grants-1997_01
Patent number
US05597846

Reaction notes

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