Hydrochloric Acid → HCID 14601405, compound

HRID 2352281Notes

Reaction equation

HRID 2352281 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[S:11][C:10]2[CH:9]=[C:8]([S:12]([NH2:15])(=[O:14])=[O:13])[S:7][C:6]=2[CH:5]=1.[ClH:16]>C(O)C>[ClH:16].[CH3:1][NH:2][CH2:3][C:4]1[S:11][C:10]2[CH:9]=[C:8]([S:12]([NH2:15])(=[O:14])=[O:13])[S:7][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14601404HCID 14601404, compound

Product 1

HCID 14601405HCID 14601405, compoundYield 83.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Methylaminomethylthieno[3,2-b]thiophene-2-sulfonamide (0.53 g., 2.0 mmoles) was dissolved in boiling ethanol (75 mL), filtered and the ethanolic solution concentrated to 50 mL. Ethanolic HCl (5.10M., 0.43 mL., 2.2 mmoles) was added to the warm solution and the flask swirled to make fine crystals. The flask was cooled in the freezer for 1.5 hours. Crystals were collected and washed with cold ethanol, and then with ether, to give 0.50 g of 5-methylaminomethylthieno[3,2-b]thiophene-2-sulfonamide hydrochloride, mp 245°-250° C. (D).

Workup

  1. filtrationfiltered
  2. concentrationthe ethanolic solution concentrated to 50 mL
  3. temperatureThe flask was cooled in the freezer for 1.5 hours
  4. customCrystals were collected
  5. washwashed with cold ethanol

Sources & evidence

ORD record
ord-eaff02c21ce44a8db3937f5c20b9e7b2
Source dataset
uspto-grants-1989_10
Patent number
US04876271

Reaction notes

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