Ethyl Acetate → HCID 70385525, compound

HRID 2352307Notes

Reaction equation

HRID 2352307 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)[NH2:3].C(OC(OCC)[CH:27]([N:30]1[C:34](=[O:35])[C:33]2=[CH:36][CH:37]=[CH:38][CH:39]=[C:32]2[C:31]1=[O:40])[CH2:28][CH3:29])C.[C:44](=O)([O-])[O-].[Na+].[Na+].C(OCC)(=O)C>C(O)(=O)C>[O:35]=[C:34]1[C:33]2[C:32](=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:31](=[O:40])[N:30]1[CH2:27][CH2:28][CH2:29][CH:44]=[N:3][NH:2][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)(=[O:12])=[O:11])=[CH:6][CH:5]=1

Participants

6

Reactant 4

HCID 8857Ethyl AcetateHCID 10340Sodium CarbonateHCID 19844127HCID 19844127, compoundHCID 19844132HCID 19844132, compound

Product 1

HCID 70385525HCID 70385525, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-hydrazino-N-(4-ethoxyphenyl)benzenesulphonamide hydrochloride (1.2 g) in 25% aqueous acetic acid (100 ml) was added to phthalimidobutyraldehyde diethyl acetal (1 g). The resulting suspension was stirred at room temperature for 1 h, basified (sodium carbonate) and extracted with ethyl acetate (2×100 ml). The combined organic extracts were dried and evaporated in vacuo to give a solid which gave the title compound (1.5 g) on trituration with ethyl acetate, m.p. 156°-158°.

Workup

  1. extractionextracted with ethyl acetate (2×100 ml)
  2. customThe combined organic extracts were dried
  3. customevaporated in vacuo
  4. customto give a solid which

Sources & evidence

ORD record
ord-9ae25bd607d440569cfa5621dfaa0b04
Source dataset
uspto-grants-1989_10
Patent number
US04876267

Reaction notes

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