Dimethyl malonate → HCID 178516639, compound

HRID 235237Notes

Reaction equation

HRID 235237 reaction equation
F[C:2]1[CH:10]=[CH:9][C:8](OC)=[CH:7][C:3]=1[C:4]([NH2:6])=[NH:5].[C:13](OC)(=[O:19])[CH2:14][C:15](OC)=[O:16]>CS(C)=O>[C:3]1([C:4]2[N:5]=[C:15]([OH:16])[CH:14]=[C:13]([OH:19])[N:6]=2)[CH:2]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 7943Dimethyl malonateHCID 21473026HCID 21473026, compound

Product 1

HCID 178516639HCID 178516639, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 2-Fluoro-5-methoxybenzamidine (10.3 g) and dimethyl malonate (8.09 g) in dry dimethyl sulfoxide (7 mL) was allowed to stand at room temperature for 24 h.. The precipitated product was collected and washed with water and ether to afford 2-Phenyl-4,6-dihydroxy-pyrimidine as a white solid.

Workup

  1. customThe precipitated product was collected
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-9ec5f1252a2241ac97785ae0a117a861
Source dataset
uspto-grants-1997_01
Patent number
US05597920

Reaction notes

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