3-Methoxypropylamine → HCID 13883399, compound

HRID 2352448Notes

Reaction equation

HRID 2352448 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH2:6].[CH:7]1([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[N:14]=[C:13](F)[N:12]=2)[CH2:9][CH2:8]1.ClCCl>O1CCCC1>[CH:7]1([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:19])([F:20])[F:18])[N:14]=[C:13]([NH:6][CH2:5][CH2:4][CH2:3][O:2][CH3:1])[N:12]=2)[CH2:8][CH2:9]1

Participants

5

Reactant 3

HCID 16723-MethoxypropylamineHCID 6344DichloromethaneHCID 13883398HCID 13883398, compound

Product 1

HCID 13883399HCID 13883399, compoundYield 977.9%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6.1 g (0.068 mol) of 3-methoxypropylamine are added dropwise at room temperature to 7 g (0.0031 mol) of 4-cyclopropylamino-2-fluoro-6-trifluoromethylpyrimidine dissolved in 100 ml of tetrahydrofuran, and the mixture is stirred for 6 hours at room temperature. After addition of 2 l of ice-water, extraction with dichloromethane, drying of the organic phase and concentrating, 8.8 g (95.4% of theory) of the desired pyrimidine are obtained.

Workup

  1. customdrying of the organic phase
  2. concentrationconcentrating

Sources & evidence

ORD record
ord-b0e21d778b03426fb491330d1b180e11
Source dataset
uspto-grants-1989_10
Patent number
US04877443

Reaction notes

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