反应详情

Ten grams of 3-cyano-N-(1,1-dimethylethyl)thiophene-2-sulfonamide was dissolved in 500 mL of trifluoroacetic acid and stirred overnight at room temperature. After removal of the solvent by evaporation, the residue was dissolved in ethyl acetate and washed with four portions of 100 mL of water followed by saturated sodium chloride. After drying over magnesium sulfate, the solvent was evaporated in vacuo to yield 6.42 g of white solid, m.p. 152°-155°. It showed peaks by Nuclear Magnetic Resonance consistent for the desired structure.

1. customAfter removal of the solvent
2. customby evaporation
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwashed with four portions of 100 mL of water
5. dry with materialAfter drying over magnesium sulfate
6. customthe solvent was evaporated in vacuo