Ethyl bromoacetate → HCID 86747676, compound

HRID 235249Notes

Reaction equation

HRID 235249 reaction equation
[N:1]1([N:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:8]2=[O:23])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].Br[CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[O:23]=[C:8]1[C:9]([CH2:16][C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)([CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]1[N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 233539641,3-dihydro-1-(piperidinyl)-3-(4-pyridinylmethyl)-2H-indol-2-one

Product 1

HCID 86747676HCID 86747676, compound

Procedure

The product obtained from Example 23 could be reacted with sodium hydride and ethyl bromoacetate in a manner similar to Example 8 to render the product as an oil. Mass Spec. Calcd. for C22H25N3O4 : 394 (M+H). Found: 394.

Sources & evidence

ORD record
ord-118f4836e05445419b4d8cc34f5223f6
Source dataset
uspto-grants-1997_01
Patent number
US05597916

Reaction notes

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