2-(4-Allyl-1-piperazinyl)-4-pentyloxyquinazoline → HCID 14424735, compound

HRID 2352513Notes

Reaction equation

HRID 2352513 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[CH2:9]([N:12]1[CH2:17][CH2:16][N:15]([C:18]2[N:27]=[C:26]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=2)[CH2:14][CH2:13]1)[CH:10]=[CH2:11]>C(O)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[CH2:9]([N:12]1[CH2:13][CH2:14][N:15]([C:18]2[N:27]=[C:26]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=2)[CH2:16][CH2:17]1)[CH:10]=[CH2:11]

Participants

4

Reactant 2

HCID 1295602-(4-Allyl-1-piperazinyl)-4-pentyloxyquinazolineHCID 444266Maleic Acid

Product 1

HCID 14424735HCID 14424735, compoundYield 58.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Ethanol (25 ml) was added to 2.3 g of maleic acid, and the mixture was heated to form a solution. A solution of 3.4 g of 2-(4-allyl-l-piperazinyl)-4-pentyloxyquinazoline in 5 ml of ethanol was added to the solution. The mixture was cooled, and the precipitated crystals were collected by filtration and recrystallized from 90 % ethanol to give 3.3 g of 2-(4-allyl-l-piperazinyl)-4-pentyloxyquinazoline dimaleate as colorless needles.

Workup

  1. temperaturethe mixture was heated
  2. customto form a solution
  3. temperatureThe mixture was cooled
  4. filtrationthe precipitated crystals were collected by filtration
  5. customrecrystallized from 90 % ethanol

Sources & evidence

ORD record
ord-556a1f48d6e746858402617f6ff93aa7
Source dataset
uspto-grants-1989_10
Patent number
US04877790

Reaction notes

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