O-Methylhydroxylamine hydrochloride → 2-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

HRID 2352703Notes

Reaction equation

HRID 2352703 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=O)[C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].Cl.[CH3:15][O:16][NH2:17]>>[CH3:15][O:16][N:17]=[C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([Cl:1])[CH:3]=1)[C:10]([OH:12])=[O:11]

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 129611392-(3-Chloro-4-hydroxyphenyl)-2-oxoacetic acid

Product 1

HCID 1360939502-Methoxyimino-2-(3-chloro-4-hydroxyphenyl)acetic acid

Procedure

(a) 2-(3-Chloro-4-hydroxyphenyl)glyoxylic acid (6.45 g.) and O-methylhydroxylamine hydrochloride (2.74 g.) were reacted according to a similar manner to that of Preparation 5-3) (a) to give oil of 2-methoxyimino-2-(3-chloro-4-hydroxyphenyl)-acetic acid (a mixture of syn and anti isomers) (7 g.).

Sources & evidence

ORD record
ord-c9de6a2651064cefa01b463824fa342c
Source dataset
uspto-grants-1989_10
Patent number
US04877873

Reaction notes

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