Hydrochloric Acid → 2-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acid

HRID 2352720Notes

Reaction equation

HRID 2352720 reaction equation
[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([O:14]CC)=[O:13])[N:10]=1)([CH3:4])(=[O:3])=[O:2].[OH-].[Na+].Cl>O>[S:1]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[O:17])[C:12]([OH:14])=[O:13])[N:10]=1)([CH3:4])(=[O:2])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19978726Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate

Product 1

HCID 199787632-(2-Mesylamino-1,3-thiazol-4-yl)glyoxylic acidYield 81.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylate (13.9 g.) was added with stirring at ambient temperature to a solution of sodium hydroxide (5.0 g.) in water (150 ml.). The mixture was stirred for 1 hour at ambient temperature, adjusted to pH 7 with conc. hydrochloric acid and washed with ethyl acetate. The aqueous layer was adjusted to pH 0.5 with conc. hydrochloric acid to precipitate yellow crystals. The crystals were collected by filtration, washed with water and dried to give 2-(2-mesylamino-1,3-thiazol-4-yl)glyoxylic acid (10.16 g.).

Workup

  1. washwashed with ethyl acetate
  2. customto precipitate yellow crystals
  3. filtrationThe crystals were collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-42a1338a6b594c69a50aedf8ac1daa74
Source dataset
uspto-grants-1989_10
Patent number
US04877873

Reaction notes

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