反应详情

温度

65 °C

A small screw cap test tube was charged with 1,5-Dimethyl-1H-pyrazole-4-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (prepared below, 134 mg, 0.333 mmol) and THF (3.3 mL). To the resulting solution was added 4-(4-methyl-piperazin-1-yl)-phenylamine (64.2 mg, 0.336 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature and concentrated in vacuo. The residue was dissolved in EtOAc (˜5 mL) and the resulting solution was triturated with Hexanes (˜40 mL). The precipitate that formed was collected by filtration and washed with 0° C. iPrOH (˜10 mL) to afford the title compound in 11% yield (0.021 g, 0.036 mmol).

1. customA small screw cap test tube
2. temperatureSubsequently, the reaction mixture was cooled to room temperature
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in EtOAc (˜5 mL)
5. customthe resulting solution was triturated with Hexanes (˜40 mL)
6. customThe precipitate that formed
7. filtrationwas collected by filtration
8. washwashed with 0° C. iPrOH (˜10 mL)