Ethanolamine → HCID 57418689, compound

HRID 2353050Notes

Reaction equation

HRID 2353050 reaction equation
[Br:1][C:2]1[N:6]2[N:7]=[C:8](Cl)[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[Br:1][C:2]1[N:6]2[N:7]=[C:8]([NH:15][CH2:14][CH2:12][OH:13])[CH:9]=[CH:10][C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 128723233-Bromo-6-chloroimidazo(1,2-b)pyridazine

Product 1

HCID 57418689HCID 57418689, compoundYield 63.8%

Procedure

400 mg (1.72 mmol) of 3-bromo-6-chloroimidazo[1,2-b]pyridazine and 2.0 ml (33.4 mmol) of ethanolamine were stirred at 90° C. for 16 h. After cooling, the mixture was concentrated. The resulting residue was purified by chromatography (DCM/EtOH 9:1). 282 mg of the product were obtained.

Workup

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated
  3. customThe resulting residue was purified by chromatography (DCM/EtOH 9:1)

Sources & evidence

ORD record
ord-94b7a938188c46c69e32877601ee37d4
Source dataset
uspto-grants-2010_07
Patent number
US07750000B2

Reaction notes

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