反应详情

To a solution of N-BOC-piperazine (300 mg) in MeCN (5 mL) was added potassium carbonate (289 mg) followed by methanesulfonic acid 5-methyl-isoxazol-3-ylmethyl ester (369 mg). The reaction mixture was heated to reflux for 24 h. After cooling the reaction mixture was diluted with water extracted into ethyl acetate, dried (MgSO4) and the solvent was removed in vacuo to yield 4-(5-methyl-isoxazol-3-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester (404 mg).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 24 h
3. temperatureAfter cooling the reaction mixture
4. extractionextracted into ethyl acetate
5. dry with materialdried (MgSO4)
6. customthe solvent was removed in vacuo