Hydrochloric Acid → HCID 57494061, compound

HRID 2353162Notes

Reaction equation

HRID 2353162 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.C([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)(OC(C)(C)C)=O.Cl.N1C=CN=C1C=O>>[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([CH2:36][C:35]4[NH:31][CH:32]=[CH:33][N:34]=4)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 249551H-imidazole-2-carbaldehydeHCID 143452tert-Butyl piperazine-1-carboxylateHCID 574940574-(2-Chloro-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 57494061HCID 57494061, compound

Procedure

ia 2-chloro-4-morpholin-4-yl-6-piperazin-1-ylmethyl-thieno[3,2-d]pyrimidine, prepared from 1-BOC-piperazine followed by treatment with HCl and subsequent reaction with imidazole-2-carboxaldehyde using standard reductive amination conditions. The amine, 2-chloro-6-[4-(1H-imidazol-2-ylmethyl)-piperazin-1-ylmethyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was subsequently isolated.

Sources & evidence

ORD record
ord-c1ca04c8a1fa4504a8507ae81d655e61
Source dataset
uspto-grants-2010_07
Patent number
US07750002B2

Reaction notes

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