Hydrochloric Acid → HCID 68426595, compound

HRID 2353242Notes

Reaction equation

HRID 2353242 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:28]>O1CCOCC1>[ClH:28].[O:20]([C:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)=[CH:15][CH:16]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57419564HCID 57419564, compound

Product 1

HCID 68426595HCID 68426595, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The title compound (0.21 g, 76%) was prepared from the compound from step 1 (0.30 g, 0.81 mmol) and 4 N HCl in dioxane by the procedure described in step 2 of Example 4: MS (ESI) m/z 269 (M+H); 1H NMR (500 MHz, DMSO-d6) δ 1.86 (br, 2H), 2.08 (m, 2H), 3.10 (br, 1H), 3.30 (br, 2H) 3.66 (m, 2H), 5.25 (br, 2H), 6.96-7.03 (m, 4H), 7.12 (m, 2H). 7.38 (m, 3H), 8.22 (br, 2H).

Sources & evidence

ORD record
ord-121b29da78f749478c15a2a47f3f2a44
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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