反应详情

The title compound (24 mg, 21%) was prepared from the compound from Example 12 (120 mg, 0.35 mmol) and 2-bromoacetic acid methyl ester (53 mg, 0.35 mmol) by the procedure described in step 1 of Example 1: MS (ESI) m/z 341 (M+H); 1H NMR (400 MHz, CDCl3) δ 1.51-1.61 (m, 4H), 1.95 (br, 2H), 2.61 (m, 11H), 2.75 (dd, J=2.4, 12 Hz, 2H), 3.56 (m, 2H), 3.75 (s, 3H), 6.90-6.96 (m, 6H), 7.03 (m, 1H), 7.28 (m, 2).