Methyl bromoacetate → HCID 68425801, compound

HRID 2353243Notes

Reaction equation

HRID 2353243 reaction equation
Cl.[O:2]([C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][CH:18]([NH2:21])[CH2:17][CH2:16]2)=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:22][O:23][C:24](=[O:27])[CH2:25]Br>>[CH3:22][O:23][C:24](=[O:27])[CH2:25][NH:21][CH:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:13]=[CH:14][C:9]([O:2][C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)=[CH:10][CH:11]=2)[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 60984Methyl bromoacetateHCID 68426595HCID 68426595, compound

Product 1

HCID 68425801HCID 68425801, compoundYield 21%

Procedure

The title compound (24 mg, 21%) was prepared from the compound from Example 12 (120 mg, 0.35 mmol) and 2-bromoacetic acid methyl ester (53 mg, 0.35 mmol) by the procedure described in step 1 of Example 1: MS (ESI) m/z 341 (M+H); 1H NMR (400 MHz, CDCl3) δ 1.51-1.61 (m, 4H), 1.95 (br, 2H), 2.61 (m, 11H), 2.75 (dd, J=2.4, 12 Hz, 2H), 3.56 (m, 2H), 3.75 (s, 3H), 6.90-6.96 (m, 6H), 7.03 (m, 1H), 7.28 (m, 2).

Sources & evidence

ORD record
ord-7d26f24cd9ee41cdb2970fec25a4ba89
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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