Sodium Hydroxide → HCID 58902530, compound

HRID 2353247Notes

Reaction equation

HRID 2353247 reaction equation
C[O:2][C:3](=[O:27])[CH2:4][CH2:5][CH2:6][N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][C:20]3[CH:25]=[CH:24][C:23]([I:26])=[CH:22][CH:21]=3)=[CH:15][CH:14]=2)[CH2:9][CH2:8]1.[OH-].[Na+:29]>>[Na+:29].[I:26][C:23]1[CH:22]=[CH:21][C:20]([O:19][C:16]2[CH:15]=[CH:14][C:13]([N:10]3[CH2:9][CH2:8][N:7]([CH2:6][CH2:5][CH2:4][C:3]([O-:27])=[O:2])[CH2:12][CH2:11]3)=[CH:18][CH:17]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 68424645HCID 68424645, compound

Product 1

HCID 58902530HCID 58902530, compoundYield 38%

Procedure

The title compound (15 mg. 38%) was prepared from the compound from step 1 (39 mg, 0.081 mmol) and 1N NaOH (0.11 mL, 0.11 mmol) by the procedure described in Example 2: MS (ESI) m/z 467 (M+1); 1H NMR (400 MHz, DMSO-d6) δ 1.59 (m, 2H), 1.83 (t, J=7.2 Hz, 2H), 2.27 (t, J=7.6 Hz, 2H), 2.47 (t, J=4.8 Hz, 4H), 3.09 (t, J=4.8 Hz, 4H), 6.74 (dd, J=2.0, 6.8 Hz, 2H), 6.91-6.98 (m, 4H), 7.63 (dd, J=2.4, 6.4 Hz, 2H).

Sources & evidence

ORD record
ord-d382d7c57aa44f6eaa4fde3fe927690b
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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