Sodium Hydroxide → HCID 58902533, compound

HRID 2353250Notes

Reaction equation

C[O:2][C:3](=[O:30])[CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]3[CH:24]=[CH:23][C:22]([C:25]4[CH:29]=[CH:28][S:27][CH:26]=4)=[CH:21][CH:20]=3)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[OH-].[Na+:32]>>[Na+:32].[S:27]1[CH:28]=[CH:29][C:25]([C:22]2[CH:21]=[CH:20][C:19]([O:18][C:15]3[CH:14]=[CH:13][C:12]([N:9]4[CH2:8][CH2:7][N:6]([CH2:5][CH2:4][C:3]([O-:30])=[O:2])[CH2:11][CH2:10]4)=[CH:17][CH:16]=3)=[CH:24][CH:23]=2)=[CH:26]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 59380348HCID 59380348, compound

Product 1

HCID 58902533HCID 58902533, compoundYield 86.3%

Procedure

The title compound (13 mg, 86%) was prepared from the compound from step 2 (15 mg, 0.035 mmol) and 1N NaOH (0.036 mL, 0.036 mmol) by the procedure described in Example 2: MS (ESI) m/z 409 (M+H). 1H NMR (400 MHz, CD3OD) δ 2.44 (m, 2H), 2.70 (t, J=4.8 Hz, 4H), 2.76 (m, 2H), 3.17 (t, J=4.8 Hz, 4H), 6.91-6.96 (m, 4H), 7.02 (m, 2H), 7.39 (dd, J=1.6, 4.8 Hz, 1H), 7.44 (m, 1H), 7.51 (dd, J=1.2, 2.8 Hz, 1H), 7.58 (m, 2H).

Sources & evidence

ORD record: ord-aad5859e2f994470bfb968990f898d12
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750012B2

Reaction notes

Loading…