Benzene, 1-iodo-4-(trifluoromethyl)- → HCID 68426458, compound

HRID 2353257Notes

Reaction equation

HRID 2353257 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[CH2:1]([N:8]1[CH2:9][CH2:10][N:11]([C:14]2[CH:15]=[CH:16][C:17]([O:20][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[CH:18][CH:19]=2)[CH2:12][CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 8690650HCID 8690650, compound

Product 1

HCID 68426458HCID 68426458, compoundYield 29.1%

Procedure

The title compound (120 mg, 25%) was prepared from 4-(4-benzyl-piperazin-1-yl)-phenol (268 mg, 1 mmol) and 1-iodo-4-trifluoromethyl-benzene (270 mg, 1 mmol) by the procedure described in step 2 of Example 17: MS (ESI) m/z 413 (M+H): 1H NMR (400 MHz, CDCl3) δ 2.63 (br, 4H), 3 18 (br, 4H), 3.58 (s, 2H), 6.92-6.98 (m, 6H), 7.32-7.35 (m, 5H), 7.52 (d, J=7.2 Hz, 2H).

Sources & evidence

ORD record
ord-2505b0c9a0194105b3c988388511a8a9
Source dataset
uspto-grants-2010_07
Patent number
US07750012B2

Reaction notes

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