Hydrochloric Acid → Sodium (6-methyl-2,5-dioxo-5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-1(2H)-yl)acetate

HRID 2353282Notes

Reaction equation

HRID 2353282 reaction equation
[CH3:1][N:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]3[N:12]([CH2:15][C:16]([O:18]C)=[O:17])[C:13](=[O:14])[N:5]([C:6]=23)[CH2:4][C:3]1=[O:20].[OH-].[Na+:22].Cl>CO>[CH3:1][N:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]3[N:12]([CH2:15][C:16]([O-:18])=[O:17])[C:13](=[O:14])[N:5]([C:6]=23)[CH2:4][C:3]1=[O:20].[Na+:22]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86629738Methyl (6-methyl-2,5-dioxo-5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-1(2H)-yl)acetate

Product 1

HCID 66636756Sodium (6-methyl-2,5-dioxo-5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-1(2H)-yl)acetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl (6-methyl-2,5-dioxo-5,6-dihydro-4H-imidazo[1,5,4-de]quinoxalin-1(2H)-yl)acetate from Step A (225 mg, 0.817 mol) in MeOH (10 mL) was added 1.0 N sodium hydroxide (1.2 mL, 1.2 mmol). After 3 h, the reaction mixture was neutralized with 1 N aqueous HCl and concentrated to give the title compound. MS: m/z=262 (M+1).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-c3c69bd9181b4cdca2d730e4de278af1
Source dataset
uspto-grants-2010_07
Patent number
US07750010B2

Reaction notes

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