Hydrogen Bromide → Carvedilol HBr

HRID 2353401Notes

Reaction equation

HRID 2353401 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[BrH:31]>C(O)C.C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[BrH:31]

Participants

5

Reactant 2

HCID 260Hydrogen Bromide2×HCID 2585Carvedilol

Product 1

HCID 9957094Carvedilol HBr

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 702EthanolSolvent

Procedure

Carvedilol free base is dissolved in ethanol, and anhydrous forms HBr is added (HBr in acetic acid). The solution is cooled, and crystallization ensues. The product is filtered, washed with process solvent, and dried.

Workup

  1. temperatureThe solution is cooled
  2. customcrystallization ensues
  3. filtrationThe product is filtered
  4. washwashed with process solvent
  5. customdried

Sources & evidence

ORD record
ord-5502836b97164baba9322403e8798c79
Source dataset
uspto-grants-2010_07
Patent number
US07750036B2

Reaction notes

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