Acetone → HCID 86602152, compound

HRID 2353405Notes

Reaction equation

HRID 2353405 reaction equation
CC(C)=O.[CH3:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][NH:16][CH2:17][CH:18]([OH:34])[CH2:19][O:20][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[NH:33][C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]=12.[C:35]([OH:40])(=[O:39])[C@H:36]([CH3:38])[OH:37]>O>[CH3:5][O:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH2:15][NH:16][CH2:17][CH:18]([OH:34])[CH2:19][O:20][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[NH:33][C:32]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:26]=12.[C:35]([O-:40])(=[O:39])[CH:36]([CH3:38])[OH:37]

Participants

5

Reactant 3

HCID 180Acetone2×HCID 2585CarvedilolHCID 107689L-Lactic Acid

Product 1

HCID 86602152HCID 86602152, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A suitable reactor is charged with acetone (50 mL). The acetone solution is sequentially charged with carvedilol (15.0 grams) and water (7 mL). Upon addition of the water, the slurry dissolves completely with heating. To the solution is added 1N aqueous D, L-Lactic acid (1 equiv., 36.9 mL). The reaction mixture is stirred at between 17° C. and 35° C. and seeded in one portion. The solid precipitate is formed over 10 hours to 24 hours. Later, the mixture is filtered and the cake is washed with a mixture of acetone and water (10 to 1) at 2 volume or 30 mL. The cake is dried under vacuum to a constant weight. The final weight is 9.16 grams.

Workup

  1. dissolutionthe slurry dissolves completely
  2. temperaturewith heating
  3. customThe solid precipitate is formed over 10 hours to 24 hours
  4. filtrationLater, the mixture is filtered
  5. washthe cake is washed with a mixture of acetone and water (10 to 1) at 2 volume or 30 mL
  6. customThe cake is dried under vacuum to a constant weight

Sources & evidence

ORD record
ord-d16e15542f714b629f0c5b806d14d8db
Source dataset
uspto-grants-2010_07
Patent number
US07750036B2

Reaction notes

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