HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Methoxycarbonylsulfamoyl)triethylammonium hydroxide → HCID 86635442, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Methoxycarbonylsulfamoyl)triethylammonium hydroxide | HCID 11032497 | — |
| Reactant | Tert-butyl 3-acetamido-4-oxopyrrolidine-1-carboxylate | HCID 68716973 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86635442 | HCID 86635442 | — |
Reaction Steps
A solution of tert-butyl 3-(acetylamino)-4-oxopyrrolidine-1-carboxylate obtained in Step B (310 mg) in tetrahydrofuran (4 mL) and (methoxycarbonylsulfamoyl)triethylammonium hydroxide (762 mg) was heated in a sealed tube at 75° C. for 3 h and evaporated under reduced pressure. The residue was then purified on a Biotage Horizon® system (silica, gradient 30-55% ethyl acetate in hexane) to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750034B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-98593084d95c44cf9e27ec5686ce6e6a |
| Source note | uspto-grants-2010_07 |