(Methoxycarbonylsulfamoyl)triethylammonium hydroxide → HCID 86635442, compound

HRID 2353443Notes

Reaction equation

HRID 2353443 reaction equation
[C:1]([NH:4][CH:5]1[C:9](=[O:10])[CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6]1)(=O)[CH3:2].[OH-].COC(NS([N+](CC)(CC)CC)(=O)=O)=O>O1CCCC1>[CH3:2][C:1]1[O:10][C:9]2[CH2:8][N:7]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][C:5]=2[N:4]=1

Participants

4

Reactant 2

HCID 11032497(Methoxycarbonylsulfamoyl)triethylammonium hydroxideHCID 68716973Tert-butyl 3-acetamido-4-oxopyrrolidine-1-carboxylate

Product 1

HCID 86635442HCID 86635442, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of tert-butyl 3-(acetylamino)-4-oxopyrrolidine-1-carboxylate obtained in Step B (310 mg) in tetrahydrofuran (4 mL) and (methoxycarbonylsulfamoyl)triethylammonium hydroxide (762 mg) was heated in a sealed tube at 75° C. for 3 h and evaporated under reduced pressure. The residue was then purified on a Biotage Horizon® system (silica, gradient 30-55% ethyl acetate in hexane) to yield the title compound.

Workup

  1. customevaporated under reduced pressure
  2. customThe residue was then purified on a Biotage Horizon® system (silica, gradient 30-55% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-98593084d95c44cf9e27ec5686ce6e6a
Source dataset
uspto-grants-2010_07
Patent number
US07750034B2

Reaction notes

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