Azobisisobutyronitrile → HCID 18947051, compound

HRID 2353447Notes

Reaction equation

HRID 2353447 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([CH2:15][C:16]#[CH:17])[CH2:12][C:13]#[CH:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[S:18]1C=CC=C1CC(O)=O.CC(N=NC(C#N)(C)C)(C#N)C>C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:12][C:13]3=[CH:14][S:18][CH:17]=[C:16]3[CH2:15]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6547AzobisisobutyronitrileHCID 159702-Thiopheneacetic acidHCID 3291474-Methyl-N,N-diprop-2-yn-1-ylbenzenesulfonamide

Product 1

HCID 18947051HCID 18947051, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of 4-methyl-N,N-diprop-2-yn-1-ylbenzenesulfonamide obtained in Step A (700 mg), thiolacetic acid (0.267 mL), and AIBN (37 mg) in benzene (90 mL) was refluxed overnight. The solvent was removed under reduced pressure, and the residue was purified on a Biotage Horizon® system (silica, gradient 30-100% dichloromethane in hexane) to yield the title compound. LC-MS 126.1 (M+1).

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was purified on a Biotage Horizon® system (silica, gradient 30-100% dichloromethane in hexane)

Sources & evidence

ORD record
ord-ccd3380c342d48a5a567c0a59ceee339
Source dataset
uspto-grants-2010_07
Patent number
US07750034B2

Reaction notes

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