Diisopropylethylamine → HCID 11168950, compound

HRID 2353559Notes

Reaction equation

HRID 2353559 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:14]([F:17])([F:16])[F:15])[C:8]([O:12][CH3:13])=[C:9]([NH2:11])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N:18]1([CH2:24][CH2:25][O:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([C:37](=[O:41])[C:38](Cl)=[O:39])=[CH:29][CH:28]=2)[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1.CCN(C(C)C)C(C)C>C(Cl)Cl>[C:1]([C:5]1[CH:6]=[C:7]([C:14]([F:15])([F:16])[F:17])[C:8]([O:12][CH3:13])=[C:9]([NH:11][C:38](=[O:39])[C:37]([C:30]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:27]([O:26][CH2:25][CH2:24][N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)=[CH:28][CH:29]=2)=[O:41])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 57503080HCID 57503080, compoundHCID 59379806HCID 59379806, compound

Product 1

HCID 11168950HCID 11168950, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5-tert-Butyl-2-methoxy-3-trifluoromethyl-phenylamine (32 mg, 0.165 mmol) was dissolved in 2 mL DCM. [4-(2-Morpholin-4-yl-ethoxy)-naphthalen-1-yl]-oxo-acetyl chloride (0.232 mmol), prepared as described before, and DIEA (0.02 mL, 0.50 mmol) were added and the reaction was stirred on. The reaction mixture was evaporated and the residue was purified by LC/MS (10-100% AcN). Calculated mass=558. Observed mass=559

Workup

  1. additionwere added
  2. customThe reaction mixture was evaporated
  3. customthe residue was purified by LC/MS (10-100% AcN)

Sources & evidence

ORD record
ord-4961b030538e40aa8193c9991ab11800
Source dataset
uspto-grants-2010_07
Patent number
US07749999B2

Reaction notes

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